IsoFlux CTC Enrichment Kit- Instructions for Use
The intended use for the IsoFlux™ Circulating Tumor Cell Enrichment Kit (CTC Kit) is as a general-purpose laboratory reagent for dilution of blood samples to enrich for circulating tumor cells (CTCs). The kit is used with the IsoFlux System, a benchtop instrument for semi-automated cell isolation. The kit contains an immunomagnetic bead reagent targeted towards cells of epithelial origin. The CTC Kit is for Research Use Only.
SUMMARY AND EXPLANATION
Circulating tumor cells (CTCs) are cancer cells that shed from a primary or metastatic tumor and enter the peripheral circulation. Carcinomas are cancers of epithelial origin and include breast, prostate, lung, and colorectal cancers. These tumors shed CTCs that are of epithelial origin. CTCs are distinct from other blood cells since cells of epithelial origin are not normally found in the circulation. The IsoFlux CTC Enrichment Kit is designed to standardize and automate the enrichment of CTCs from biological samples using the IsoFlux System. CTCs are enriched from the sample using an immunomagnetic capture reagent while the sample flows through a microfluidic cartridge designed for cellular isolation. The kit produces an enriched cell pellet that can subsequently be used for further testing.
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